Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: A diagnostic challenge
نویسندگان
چکیده
منابع مشابه
Systemic mastocytosis with associated acute myelogenous leukemia.
Systemic mastocytosis (SM) is a condition associated with a clonal neoplastic proliferation of mast cells. Approximately 40% of patients with SM present with an associated clonal hematological non-mast cell lineage disorder. Patients presenting with SM-acute myeloid leukemia (AML) have the worst prognosis. We present a case of a 62-year-old woman who was diagnosed with SM-AML. After initial tre...
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متن کاملA Case of Systemic Mastocytosis Associated with Acute Myeloid Leukemia Terminating as Aleukemic Mast Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation
In up to 40% of systemic mastocytosis (SM) cases, an associated clonal hematological non-mast cell lineage disease such as AML is diagnosed before, simultaneously with, or after the diagnosis of SM. A 40-yr-old man was diagnosed with AML with t(8;21)(q22;q22). Mast cells were not noted at diagnosis, but appeared as immature forms at relapse. After allogeneic hematopoietic stem cell transplantat...
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AHNMD: associated clonal hematologic none mast cell lineage disease CM: cutaneous mastocytosis CMML: chronic myelomonocytic leukemia MPCM: maculopapular cutaneous mastocytosis SM: systemic mastocytosis INTRODUCTION Maculopapular cutaneous mastocytosis (MPCM) is the clinical variant of cutaneous mastocytosis (CM) most frequently observed in adults, usually within the context of an indolent syste...
متن کاملSystemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia
Although KIT mutations are present in 20-25% of cases of t(8;21)(q22;q22) acute myeloid leukemia (AML), concurrent development of systemic mastocytosis (SM) is exceedingly rare. We examined the clinicopathologic features of SM associated with t(8;21)(q22;q22) AML in ten patients (six from our institutions and four from published literature) with t(8;21) AML and SM. In the majority of these case...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2010
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21713